History museums are never short of public interest and quite a few have been established in Cheshire, illustrating thousands of years of expansion and struggles. Some of the most notable include the Dewa Roman Experience and the Grosvenor Museum in Cheshire, the latter being more wide-ranging yet exhibiting many Roman artefacts. Reminiscent of Cheshire's Latin heritage, the Dewa Roman Experience in Cheshire offers a very vivid experience, particularly to children, teaching them about Roman Chester in an interactive way, and includes a rebuilt Roman street.

Exhibiting features of silk manufacturing, which was an economic strong point of the county for many decades, the Silk Museum located in Paradise Mill is only one of four museums in Macclesfield dedicated exclusively to this material. The Lion Salt Works in Marston is also centred on this trade. Another notable exploit of the area, namely salt, is documented at Weaver Hall Museum in Nortwich (previously referred to as the Salt Museum), where one can also see archaeological displays, as well as aspects of local history.

Those who are intrigued by the evolution of internal combustion engines also stop at the Anson Engine Museum in Poynton, which has gained countrywide recognition for its comprehensiveness and where a large number of very early engine prototypes of all sizes are on display. Also, in Ellesmere Port, one can pay a visit to the National Waterway Museum, focused on the history of Cheshire's ample network of canals.

Besides museums documenting conventional aspects, there are many others, often founded by passionate collectors. There is the Chester Toy and Doll Museum, for instance, which preserves toys manufactured as far back as the 1860s. There is also a Museum of Amusements in Tattenhall, offering a unique chance to experience old mechanical amusements and ventriloquism. Also, not to be missed, the Museum of Policing in Cheshire is located in Warrington.